Product Description
Experimental characteristics
Merck:9681
Refractive index: 1.2850
Water solubility: miscible
Boiling point: 72-73 °c
Melting point: -15.4 °c
Vapor pressure: 97.5 mmHg (20 °C)
Flash point: Fahrenheit: >212 °F
Celsius: >100 °C
Solubility: Miscible with ether, acetone, ethanol, benzene, hexane, and CCl4
Color and properties: colorless, transparent hygroscopic fuming liquid, strong pungent odor.
PH: 1 (10g/l, H2O)
Stability: Stable. Incompatible with combustible material, strong bases, water, strong oxidizing agents. Non-combustible. Hygroscopic. May react violently with bases.
Solubility: soluble in water, ethanol, ether, acetone, benzene.
Sensitivity: Sensitive to humidity
Acidity coefficient (pKa): -0.3 (at 25°C)
Density: 1.4890
Use
First, the product is a good solvent for many organic compounds, combined with carbon disulfide, can dissolve proteins. It is also an excellent solvent for organic reactions. Results that are difficult to obtain in general organic solvents can be obtained.
Second, trifluoroacetic acid is an important reagent for organic synthesis, by which it can synthesize various fluorinated compounds, pesticides and dyes. Trifluoroacetic acid is also a catalyst for esterification and condensation reactions; It can also be used as a protective agent for hydroxyl and amino groups for the synthesis of sugars and peptides.
Third, trifluoroacetic acid (TFA) is a commonly used organic acid in chemical laboratories, because the carboxyl group ortho-carbon is connected with 3 relatively strong electronegative group fluorine atoms, so the nucleophility of carboxylate is greatly reduced, so trifluoroacetic acid is often used as a solvent to study the solvent effect of the reaction. Trifluoroacetic acid has a relatively low boiling point, good volatility, and strong acidity, so it can catalyze many acid-catalyzed chemical reactions, and post-treatment is relatively easy and can be removed by vacuum distillation. In addition, trifluoroacetic acid can participate in oxidation reactions, reduction reactions, rearrangement reactions and deprotection groups.
Fourth, used as a test reagent, solvent, catalyst and for organic synthesis.
Production method
First, it was prepared by oxidation of 2,3-dichlorohexafluoro-2-butene;
Second, 2,3-dichlorohexafluoro-2-butene was oxidized with fluorine as a catalyst to prepare it;
Third, trifluoroacetic acid can be prepared by oxidation of 3,3,3-trifluoropropene by potassium permanganate, or by the reaction of trichloroacetonitrile with hydrogen fluoride to generate trifluoroacetonitrile and then hydrolysis, or electrochemical fluorination of acetic acid (or acetic anhydride). Refining method: distillation and refining under a stream of nitrogen. Or add phosphorus pentoxide to reflux and distill. Further purification can be crystallized in steps followed by distillation.
Fourth, trifluoroacetic acid can be prepared by oxidation of 3,3,3,-trifluoropropene by potassium permanganate; or by the reaction of trichloroacetonitrile and hydrogen fluoride, trifluoroacetonitrile is first generated, and then hydrolyzed; It can also be prepared by electrochemical fluorination of acetic acid or acetic anhydride.
| Trifluoroacetic acid Basic information |
| Product Name: |
Trifluoroacetic acid |
| CAS: |
1976/5/1 |
| MF: |
C2HF3O2 |
| MW: |
114.02 |
| EINECS: |
200-929-3 |
| Trifluoroacetic acid Chemical Properties |
| Melting point |
-15.4 °C (lit.) |
| Boiling point |
72.4 °C (lit.) |
| density |
1.489 g/mL at 20 °C (lit.) |
| vapor density |
3.9 (vs air) |
| vapor pressure |
97.5 mm Hg ( 20 °C) |
| refractive index |
n20/D 1.3(lit.) |
| Fp |
None |
| storage temp. |
2-8°C |
| form |
Liquid |
| pka |
-0.3(at 25ºC) |
| color |
Colorless |
| Specific Gravity |
1.48 |
| Odor |
Sharp, pungent odor |
| PH |
1 (10g/l, H2O) |
| PH Range |
1 |
| Water Solubility |
miscible |
| Merck |
149,681 |
| BRN |
742035 |
| InChIKey |
DTQVDTLACAAQTR-UHFFFAOYSA-N |
| CAS DataBase Reference |
76-05-1(CAS DataBase Reference) |
| NIST Chemistry Reference |
Acetic acid, trifluoro-(76-05-1) |
| EPA Substance Registry System |
Acetic acid, 2,2,2-trifluoro- (76-05-1) |
| Item |
Index |
| Top grade |
First grade |
Qualified product |
| Trifluoroacetic acid , % ≥ |
99.5 |
99 |
99 |
| HCL, % ≤ |
0.1 |
0.15 |
0.3 |
| HF, % ≤ |
0.01 |
0.05 |
0.1 |
Yujiang Chemical (Shandong) Co., Ltd. We are located in Shandong with convenient transportation access. We are a professional manufacturer and trader that is concerned with the research, development and production of Chemical, Minerals and Plastic raw materials, We committed to providing you with high-quality products and services.
We committed to providing you with high-quality products and services. We always implement the concept of customer value creation, for customers tailored products. Meet the needs of different customers, and continuously provide customers with solutions and technical problems. Further exploration and innovation, and excellence.Welcome and look forward to customers from all of the world to contact us for create a bright future with us together.
1.Q: Where is your company located? How can I visit there?
A: Our factory is located in Qingdao City, China.
2. Q: Can I get sample and how long will it take?
A: Yes. We can supply sample. And you need to pay for the sample and courier.About 2days after receiving the payment, we will send it out.
3. Q: What's the MOQ?
A: Our MOQ is one 20'container.
4. Q: Can I have my own customized product?
A: Yes. Your customized requirements for logo, design, package, your language manual etc. We are very welcome.
5. Q: Can I mix different models in one container?
A: Yes. Different models can be mixed in one container.
6. Q: What's the delivery time?
A: It will take about 10-15 days to finish an order. But the exact time is according to actual situation.
7. Q: What is the payment terms?
A: T/T, L/C and so on.(Contact with customer our service.)
8. Q: How does your factory carry out quality control?
A: We attach great importance to quality control.Every part of our products has its own QC.
9. How do you make our business long-term and good relationship?
A:1. We keep good quality and competitive price to ensure our customers benefit ;
2. We respect every customer as our friend and we sincerely do business and make friends with them, no matter where they come from.
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